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Introducing CHILL
A research study exploring a potential new one-time treatment for difficult to treat rheumatoid arthritis or scleroderma.
WHAT is CHILL?
CHILL is a clinical study testing an experimental medicine. It aims to find out how this medicine affects people living with scleroderma or rheumatoid arthritis, and understand whether it is suitable for further development as a new treatment option.
WHO can take part?
The CHILL study is open to adults aged 18 or over living with certain forms of difficult to treat rheumatoid arthritis or scleroderma. It aims to enrol 4-6 scleroderma participants and 6-10 rheumatoid arthritis participants. Recruitment for the CHILL study will start in early 2026. You must also meet certain requirements, known as eligibility criteria, to take part in the CHILL study. Some key criteria are outlined below, but additional eligibility requirements will need to be assessed by your doctor.
Key Inclusion Criteria
- Diagnosis of difficult to treat rheumatoid arthritis or scleroderma
- Adults aged 18 or over
Key Exclusion Criteria
- Living with a clinical condition that may impact the ability to undergo study procedures
- Living with an active or chronic infection such as HIV, Hepatitis B or active Tuberculosis
- A history of any drug or alcohol misuse in the past 2 years
- Currently pregnant or breastfeeding
- Currently taking certain medications that may be prohibited
How LONG is the study?
For people who take part in the study, involvement will last for 12 months. After this, all participants will have their health checked once a year for an additional 14 years.
WHERE is CHILL taking place?
CHILL is a multinational clinical study that will recruit participants across study sites/hospitals in the UK, Germany and Spain. If you would like to speak to a participating site about potential involvement, please see the following contact details:
Patient Advocacy Groups
Where can I learn more about scleroderma and rheumatoid arthritis?
Patient groups are an excellent source of up-to-date information and valuable support for people living with a variety of diseases and for their loved ones. The links below are intended to help people living with scleroderma or rheumatoid arthritis find local support and information in their own language.
Scleroderma
Rheumatoid arthritis
I am interested in taking part… how can I find out more?
If you have been diagnosed with scleroderma or rheumatoid arthritis, meet the key criteria listed above, and would like more information about taking part, you can find additional supporting resources here. Please speak with your current healthcare provider to discuss if this study may be appropriate for you to take part in.